End-to-End Solutions in Nucleic Acid Chemistry…Precision. Partnership. Performance.

Overview

At Cohance Lifesciences, we deliver comprehensive solutions in nucleic acid chemistry enabling the advancement of cutting-edge therapeutics from early-stage research to commercial supply. Our capabilities span custom nucleic acid synthesis, including Phosphoramidites and Nucleoside Triphosphates, along with robust process development, scale-up, and GMP-grade manufacturing. We cater to therapeutic companies developing commercial drugs based on ASOs, siRNAs, aptamers, and other emerging nucleic acid modalities.

With Sapala Organics as our strategic partner, we bring differentiated strength in complex nucleoside chemistry and custom synthesis — reinforcing our ability to deliver precision and performance at every stage. Together, we offer a seamlessly integrated platform for nucleic acid building blocks and therapeutic development.

Backed by scientific depth, advanced infrastructure, and global regulatory alignment, Cohance is a trusted partner to biotech and pharmaceutical innovators worldwide. Our dedicated nucleic acid platforms are designed for agility, scalability, and quality…ensuring you move confidently across the development lifecycle.

 
Nucleic Acid Chemistry Landing Page

Why Partner with Cohance for
Nucleic Acid Chemistry?

why-choose-cohance-nucleic-acid-chemistry

Why Partner with Cohance for
Nucleic Acid Chemistry?

  • Comprehensive nucleic acid development and manufacturing services
  • Proven expertise in modified Phosphoramidites, NTPs, Linkers, and delivery compounds
  • Advanced synthesis platforms for complex sequences and high-purity needs
  • Process optimization and scale-up readiness for clinical and commercial milestones
  • cGMP manufacturing facilities aligned with USFDA, EMA, and PMDA requirements
  • Integrated analytical development with robust impurity profiling
  • Seamless project execution across development and manufacturing stages

Our Integrated Capabilities

Custom synthesis for early-stage development
Process design, optimization, and scale-up
High-purity Phosphoramidite purification and polishing
Analytical method development, characterization, and stability studies
Full cGMP manufacturing with multi-kilo capacity
Regulatory documentation and global filings
Lifecycle management including reprocessing and yield enhancement
Custom synthesis for early-stage development
Process design, optimization, and scale-up
High-purity Phosphoramidite purification and polishing
Analytical method development, characterization, and stability studies
Full cGMP manufacturing with multi-kilo capacity
Regulatory documentation and global filings
Lifecycle management including reprocessing and yield enhancement

Let’s advance your oligonucleotide and mRNA programs with confidence-from idea to impact.