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Innovative Payloads for next generation ADCs.
Overview
Cohance Lifesciences is a global frontrunner in the development and supply of high-potency payloads and linkers for Antibody-Drug Conjugates (ADCs). With deep expertise in Camptothecin (CPT) derivatives and proprietary s-Trione scaffold, we offer customizable payloads with high cytotoxicity, efficient conjugation, and scalable synthesis.
Our capabilities span from early-stage R&D to GMP-compliant commercial manufacturing, all under rigorous global standards for quality, containment, and regulatory compliance. We specialize in handling ultra-potent compounds with occupational exposure limits (OEL) as low as ~10 µg/m³.
Why Cohance for Small Molecule Manufacturing?
Why Cohance for ADC Payloads?
- Global Innovator in synthetic CPT derivatives, powered by proprietary S-Trione technology.
- Expertise in High-Potency Payloads, ensuring safety, scalability, and therapeutic efficacy.
- Robust Backward Integration for consistent supply of key starting materials (KSMs), including (s)-Trione, tetralone derivative (CAS# 182182-31-6) etc.
- Sustainability Commitment, backed by ISO 14001, 45001, and 9001 certifications, with measurable ESG impact: 17% water savings, 6% CO₂ reduction, and over 33,000 trees planted.
Core Capabilities
CPT Derivative
Expertise
Advanced synthetic routes for Exatecan Mesylate, SN-38, Irinotecan, Topotecan, 10-Hydroxy Camptothecin, and more, with integrated supply of intermediates like (s)-Trione (CAS# 110351-94-5).
Regulatory
Strength
Active Drug Master Files (DMFs) for S-Trione (US DMF 039042), SN-38 (US DMF 039031), Irinotecan (CEP 2023-338) and with upcoming DMFs for Exatecan, Dxd, Belotecan and MMAE.
Proprietary
s-Trione Platform
Engineered payloads with superior stability and therapeutic index, enabling precision-targeted ADCs.
Auristatin
Development
Optimized processes for Monomethyl Auristatin E (MMAE), ensuring impurity control and batch consistency.
GMP Manufacturing
Excellence
Multi-kilogram production in specialized cytotoxic facilities, supporting both clinical trials and commercial supply.
CPT Derivative
Expertise
Advanced synthetic routes for Exatecan Mesylate, SN-38, Irinotecan, Topotecan, 10-Hydroxy Camptothecin, and more, with integrated supply of intermediates like (s)-Trione (CAS# 110351-94-5).
Regulatory
Strength
Active Drug Master Files (DMFs) for S-Trione (US DMF 039042), SN-38 (US DMF 039031), Irinotecan (CEP 2023-338) and with upcoming DMFs for Exatecan, Dxd, Belotecan and MMAE.
Proprietary
s-Trione Platform
Engineered payloads with superior stability and therapeutic index, enabling precision-targeted ADCs.
Auristatin
Development
Optimized processes for Monomethyl Auristatin E (MMAE), ensuring impurity control and batch consistency.
GMP Manufacturing
Excellence
Multi-kilogram production in specialized cytotoxic facilities, supporting both clinical trials and commercial supply.
Payload & Linker Services
Cohance Lifesciences offers end-to-end payload and linker development tailored to the evolving needs of Antibody-Drug Conjugates (ADCs). Our services combine scientific precision with scalable manufacturing to ensure consistency, safety, and regulatory compliance.
Our Expertise
Process
Optimization
Scalability studies, impurity profiling, validation under Quality by Design (QbD) principles and analytical method development & validation.
Custom Payload
Synthesis
Tailored Camptothecin (CPT) and Auristatin derivatives designed for optimal cytotoxicity and linker compatibility.
Linker
Development
Synthesis of industry-standard and proprietary linkers, including: Maleimide, Hydrazone, SMCC, MC-VC-PAB, PNP-PAB-m-PhosphatePEG8-DBCO
Containment
Expertise
Safe handling of high-potency compounds in both R&D and GMP settings using isolators and negative pressure systems.
Facilities
API R&D Unit-III, Nacharam
Hyderabad, India
API Unit IV, Nacharam (CDMO)
Hyderabad, India
API Unit V, Parwada
Vizag, India
Designed to seamlessly scale from clinical to commercial manufacturing, these facilities are compliant with global regulatory standards including the US FDA.
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