Precision Development for Advanced Products for Oligonucleotide Therapeutics From concept to IND-tailored chemistry, scalable support.
Sapala Organics, backed by Cohance Lifesciences, offers end-to-end development support for nucleic acid-based therapeutics, from route scouting to IND-enabling synthesis. With deep expertise in phosphoramidite chemistry and nucleoside modification, we help innovators optimize molecular design and synthesis. Our integrated approach ensures speed, scalability, and regulatory alignment from lab to manufacturing floor.
Why Choose Sapala for Nucleic Acid Development?
Why Choose Sapala for Nucleic Acid Development?
- India’s only CDMO dedicated to nucleic acid chemistry
- End-to-end integration with scale-up and GMP manufacturing
- Collaborative, client-centric approach to synthesize complex nucleic acids for Oligo and mRNA synthesis
- Proven support for discovery-to-IND transitions
- Integrated collaboration with GMP manufacturing units
- Agile engagement model tailored to complex nucleic acid challenges
Core Development Capabilities
Route
Scouting
Feasibility and pathway optimization for modified nucleosides, phosamidites, and mRNA intermediates.
Custom
Synthesis
Tailored building blocks including GalNAc conjugates, NTPs, CAP reagents, and dyes.
Analytical
Development
Method development, impurity profiling, and characterization
Regulatory
Support
IND-enabling documentation and collaboration.
Integrated Development Services
Integrated CDMO services across the Oligonucleotide and mRNA lifecycle
Custom
Synthesis
Design and synthesis of proprietary and modified nucleic acid building blocks—including high-purity phosphoramidites, NTPs, and CAP reagents—tailored to client-specific needs.
Contract Development
& Manufacturing
Scalable process development from milligram to multi-kilogram quantities. Both non-GMP and GMP execution are carried out under Cohance’s validated quality systems and aligned with global regulatory standards.
FTE Engagement
Models
In-house analytical labs with advanced instrumentation and characterization capabilities for data-driven development.
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