Integrated CRDMO Services for ADCs

At the intersection of complex chemistry and precision biology, Cohance Lifesciences and NJ Bio offer integrated CRDMO (Contract Research, Development, and Manufacturing Organization) services tailored for Antibody-Drug Conjugates (ADCs). From linker-payload synthesis to bioconjugation and clinical-scale GMP production, we support your ADC programs across all development stages and follow-up studies with seamless execution and quality-focused approach.

Our integrated CRDMO model is designed for agility, scale, and regulatory readiness—helping biopharma innovators bring safer, more effective ADCs to market, faster.

Why Cohance + NJ Bio for Integrated CRDMO Services?

Deep expertise in ADC domain, with integrated knowledge spanning chemistry, biology, and manufacturing
Purpose-built facilities for bioconjugation and HPAPI containment
Market leaders in S-Trione production, the key intermediate for camptothecin-based payloads
Operational stability and de-risked supply chain
Agile and collaborative CRDMO partnership with regulatory foresight

Core Capabilities

Innovative
Bioconjugation Platforms

Expertise in both site-specific and conventional/stochastic conjugation with process optimization to ensure consistency, stability and clinical readiness for ADCs.

In-house
Synthesis

Reliable production of chemical building blocks and complex intermediates, reducing dependency on external suppliers, ensuring supply chain stability and optimizing both cost & timelines of the project.

Unique Chemistry
Solutions

We recognize that every molecule presents distinct challenges, and we customize our chemistry strategies to align with each program’s goals and target biology.

Customized & Scalable
Linker-Payload Synthesis

Tailored synthesis with process optimization to ensure efficiency, reproducibility and scalability.

Scalable GMP
Manufacturing

Phase-appropriate production in state-of-the-art facilities with global regulatory compliance.

Analytical &
Regulatory Support

CMC development, complete characterization& qualified methods, submission-ready documentation.

Problem-solving
Expertise

Proven capabilities in complex chemistry allows for effective resolution of inherent challenges in ADC development.

Comprehensive Services

Discovery to IND Support

Early discovery, rapid proof-of-concept (PoC), synthesis of linker-payload variants, conjugation feasibility, and lead candidate selection.

Integrated Analytics

Comprehensive characterization approach combining bioanalytical assays (LC-MS, ELISA, hybrid assays); functional assays (cytotoxicity, receptor binding, antibody internalization); and advanced BioNMR for structural evaluation.

Process Development

Route scouting, impurity profiling, DoE optimization, and tech transfer.

Bioconjugate Development

Selection of optimal bioconjugation strategies for enhanced stability and targeting.

GMP Manufacturing

Clinical supply of ADCs and intermediates for Phase 1 & 2 trials, with scalable linker-payload production capabilities to support commercial manufacturing.

Facilities

Designed to seamlessly scale from clinical to commercial manufacturing, these facilities are compliant with global regulatory standards including the US FDA.

Integrated CRDMO