Nucleosides & Phosphoramidites Development
Precision Development for Advanced Products for Oligonucleotide Therapeutics From concept to IND-tailored chemistry, scalable support.
Overview
Sapala Organics, backed by Cohance Lifesciences, offers end-to-end development support for nucleic acid-based therapeutics, from route scouting to IND-enabling synthesis. With deep expertise in phosphoramidite chemistry and nucleoside modification, we help innovators optimize molecular design and synthesis. Our integrated approach ensures speed, scalability, and regulatory alignment from lab to manufacturing floor.
Key Highlights
Infrastructure
2 multipurpose production blocks and 1 dedicated hydrogenation block
Capacity
750 KL with varied reactor sizes and utility configurations
Scalability
Provision to add 3 additional multipurpose blocks
Technical Capability
Expertise in 30+ complex chemistries viz. Chlorination, Cyanation, Suzuki coupling, Cryo reaction, Grignard reaction, Carbonylation etc
Commitment to Quality,
Safety & Sustainability
Every batch is governed by rigorous safety protocols and eco-friendly practices to meet global standards.
Strong Track Record with
Global Agrochemical Majors
We are trusted partners to industry leaders, enabling success through innovation and reliable delivery.
Genome Valley R&D Center
25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites
Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites
Plug flow reactors, Corning G1 systems, and photo flow platforms.
Why Cohance for Small Molecule Manufacturing?
Why Choose Sapala for Nucleic Acid Development?
- India’s only CDMO dedicated to nucleic acid chemistry
- End-to-end integration with scale-up and GMP manufacturing
- Collaborative, client-centric approach to synthesize complex nucleic acids for Oligo and mRNA synthesis
- Proven support for discovery-to-IND transitions
- Integrated collaboration with GMP manufacturing units
- Agile engagement model tailored to complex nucleic acid challenges
Why Choose Cohance for Agrochemical CDMO Services?
We offer end-to-end solutions across the agrochemical lifecycle-from R&D to commercialization-ensuring reliable, scalable, and cost-efficient support tailored to your needs.
Global Regulatory
Expertise
We bring in-depth knowledge of REACH, EPA, and global certifications—ensuring smooth compliance and market entry.
Advanced R&D and
Scale-Up Capabilities
Our R&D labs excel in route scouting, process development, and scaling complex agrochemical molecules efficiently.
Integrated Supply Chain
for Cost & Time Gains
From synthesis to delivery, our end-to-end integration ensures speed, quality, and cost optimization.
Commitment to Quality,
Safety & Sustainability
Every batch is governed by rigorous safety protocols and eco-friendly practices to meet global standards.
Strong Track Record with
Global Agrochemical Majors
We are trusted partners to industry leaders, enabling success through innovation and reliable delivery.
Genome Valley R&D Center
25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites
Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites
Plug flow reactors, Corning G1 systems, and photo flow platforms.
Manufacturing Strengths
Manufacturing Strengths
Scalable Production: Flexible volumes from gram to multi-ton capacity across multiple sites.
GMP-Ready Infrastructure: USFDA-, EMA-, and PMDA-approved sites with validated processes and full traceability.
Technology-Enabled Execution: Flow reactors, high-pressure systems (up to 20 kg/cm²), cryogenic capabilities (-70°C), and automation.
Regulatory Compliance: 200+ DMFs filed globally; extensive experience in audits and global market readiness.
Lifecycle Manufacturing: Support for reprocessing, impurity purge, solvent recovery, and green manufacturing practices.
Our Capabilities
Scalable
Production
Flexible volumes from gram to multi-ton capacity across multiple sites.
GMP-Ready
Infrastructure
USFDA-, EMA-, and PMDA-approved sites with validated processes and full traceability.
Technology-Enabled
Execution
Flow reactors, high-pressure systems (up to 20 kg/cm²), cryogenic capabilities (-70°C), and automation.
Regulatory
Compliance
200+ DMFs filed globally; extensive experience in audits and global market readiness.
Lifecycle
Manufacturing
Support for reprocessing, impurity purge, solvent recovery, and green manufacturing practices.
30+ years of expertise in agrochemicals and specialty chemical solutions
ISO-certified (9001, 14001, 45001), cGMP-compliant R&D and manufacturing sites
ISO-certified (9001, 14001, 45001), cGMP-compliant R&D and manufacturing sites
Validated systems with in-house EHS teams
Validated systems with in-house EHS teams
Process Safety
& Risk Evaluation
State-of-the-art safety studies (RC1, DSC, ARC) to ensure secure scale-up.
Regulatory
Documentation
Comprehensive support for IND, IMPD, and DMF submissions across global markets.
Core Development Capabilities
Scalable
Production
Flexible volumes from gram to multi-ton capacity across multiple sites.
GMP-Ready
Infrastructure
USFDA-, EMA-, and PMDA-approved sites with validated processes and full traceability.
Technology-Enabled
Execution
Flow reactors, high-pressure systems (up to 20 kg/cm²), cryogenic capabilities (-70°C), and automation.
Regulatory
Compliance
200+ DMFs filed globally; extensive experience in audits and global market readiness.
Lifecycle
Manufacturing
Support for reprocessing, impurity purge, solvent recovery, and green manufacturing practices.
30+ years of expertise in agrochemicals and specialty chemical solutions
ISO-certified (9001, 14001, 45001), cGMP-compliant R&D and manufacturing sites
Strategic partnerships with leading agrochemical and chemical companies
Route
Scouting
Feasibility and pathway optimization for modified nucleosides, phosamidites, and mRNA intermediates.
Custom
Synthesis
Tailored building blocks including GalNAc conjugates, NTPs, CAP reagents, and dyes.
Analytical
Development
Method development, impurity profiling, and characterization
Regulatory
Support
IND-enabling documentation and collaboration.
Process Safety
& Risk Evaluation
State-of-the-art safety studies (RC1, DSC, ARC) to ensure secure scale-up.
Regulatory
Documentation
Comprehensive support for IND, IMPD, and DMF submissions across global markets.
Facilities
Genome Valley R&D Center: 25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites: Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites: Plug flow reactors, Corning G1 systems, and photo flow platforms.
Integrated Development Services
Integrated CDMO services across the Oligonucleotide and mRNA lifecycle
Custom
Synthesis
Design and synthesis of proprietary and modified nucleic acid building blocks—including high-purity phosphoramidites, NTPs, and CAP reagents—tailored to client-specific needs.
Contract Development
& Manufacturing
Scalable process development from milligram to multi-kilogram quantities. Both non-GMP and GMP execution are carried out under Cohance’s validated quality systems and aligned with global regulatory standards.
FTE Engagement
Models
In-house analytical labs with advanced instrumentation and characterization capabilities for data-driven development.
Process Safety
& Compliance
Hazard assessment studies and regulatory support aligned with REACH, EPA, and other global standards.
Integrated Supply Chain
& Lifecycle Management
Cost-optimized logistics, inventory support, and environmentally responsible process management.
Genome Valley R&D Center
25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites
Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites
Plug flow reactors, Corning G1 systems, and photo flow platforms.
Specialized Products
Amidites &
Nucleosides
Modified chemistries including locked/bridged nucleic acids, FANA, morpholinos, tri-cyclo DNA
GalNAc
Conjugates
PEG linkers, lipid conjugates, and sugar derivatives for drug delivery
mRNA Building
Blocks
N1-Me-pseudouridine and CAP reagents produced at multi-kg scale
Fluorescent
Dyes
Large-scale synthesis of Cy dyes, TAMRA, 6-FAM, and others
Nucleosides & Phosphoramidites Manufacturing
Scalable GMP Manufacturing for Oligo Building Blocks
Overview
Backed by Cohance Lifesciences, Sapala Organics delivers GMP-compliant manufacturing of oligonucleotide intermediates at scale. Our infrastructure includes dedicated amidite blocks, ISO-grade cleanrooms, and versatile reactors to support GalNAc compounds, modified nucleosides, mRNA reagents, and fluorescent dyes. With capacity from 100 g to 100+ kg, we support clinical and commercial supply with validated processes and global regulatory alignment.
Why Cohance + Sapala for Oligonucleotide Manufacturing?
Integrated CDMO services across the Oligonucleotide and mRNA lifecycle
Only Indian CDMO with deep nucleic acid scale-up capabilities
Only Indian CDMO with dedicated infrastructure for oligonucleotide intermediates
Proven GMP compliance
Audit-ready, globally aligned documentation
Flexible delivery—from 100 g R&D batches to 100+ kg GMP lots
Proven execution across GalNAc, fluorescent dyes, and mRNA reagents
Process rigor supported by validated SOPs, batch traceability, and regulatory readiness
Backed by Cohance Lifesciences’ global compliance framework
Process Safety
& Compliance
Hazard assessment studies and regulatory support aligned with REACH, EPA, and other global standards.
Integrated Supply Chain
& Lifecycle Management
Cost-optimized logistics, inventory support, and environmentally responsible process management.
Custom-Fit Execution Models
Integrated CDMO
Manufacturing
Comprehensive services from late-stage development to GMP batch production, ensuring regulatory-aligned manufacturing.
Flexible Delivery
& Engagement
Choose from fixed-scope or FTE-based models to match your scale, timelines, and internal capabilities.
End-to-End
Accountability
Combined expertise in complex synthesis and rigorous manufacturing makes Sapala a seamless CDMO partner from development to commercial readiness.
Manufacturing Infrastructure Highlights
Integrated CDMO services across the Oligonucleotide and mRNA lifecycle
600–700 kg/year Capacity at dedicated GMP amidite unit (Nacharam)
ISO Class 8 / Grade D Cleanrooms with HEPA filtration and RH control for sensitive drying and dispensing
Versatile Reactor Suite: 10+ reactors (glass, stainless steel, Hastelloy) ranging from 50 L to 1,000 L
Advanced Equipment: Lyophilizers, Nutsche filters, rotavapors, and large-volume glass columns
USFDA-Approved Unit 4 being equipped for commercial-scale GMP phosphoramidite manufacturing
Upcoming Expansion: GMP readiness by September 2025, enabling larger volume delivery for clinical and commercial needs
Process Safety
& Compliance
Hazard assessment studies and regulatory support aligned with REACH, EPA, and other global standards.
Integrated Supply Chain
& Lifecycle Management
Cost-optimized logistics, inventory support, and environmentally responsible process management.
Dedicated Phosphoramidite - GMP (Nacharam)
1
Kgs
Annual
capacity
capacity
1
ISO Class Cleanroom
& Intermediate Area
& Intermediate Area
<
1
%
RH with terminal
HEPA filtration
HEPA filtration
1
Units
Plant Reactors
50L - 1,000L
50L - 1,000L
1
Units
Kilo Lab Reactors
10L - 50L
10L - 50L
0
Manufacturing Sites
0
USFDA/EDQM Accredited Sites
0
+ KL
Reactor Capacity
Facilities
We operate a versatile network of specialty chemicals (Spec Chem) R&D and manufacturing facilities across India. Our infrastructure is tailored to support the development and commercial production of high-value intermediates and performance chemicals — with agility, scalability, and compliance at its core.
Genome Valley R&D Center
25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites
Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites
Plug flow reactors, Corning G1 systems, and photo flow platforms.
Our Spec Chem labs are optimized for process development, hazard evaluation, and scale-up readiness of specialized chemical intermediates.
Sapala Organics, IDA Mallapur
Pilot Plant, Nacharam
Unit 2, Jeedimetla
Unit 4, Nacharam (USFDA-Approved)
Sapala Organics, IDA Mallapur
Hyderabad, India
Our pilot and commercial-scale Specialty Chem facilities are engineered for multipurpose operations — enabling flexible batch production, robust scale-up, and safe manufacturing. (~3,000+ kL Capacity)
CDMO Unit-II, Jeedimetla
Hyderabad, India
API Unit IV, Nacharam
Hyderabad, India
Genome Valley R&D Center
25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites
Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites
Plug flow reactors, Corning G1 systems, and photo flow platforms.
From grams to tons-trust Cohance to deliver your small molecule at scale.
Contact Manufacturing Team
Looking to scale your oligonucleotide program with high-purity building blocks and GMP assurance?
Contact UsResources
- Webinar: Advancing Agrochemical Solutions for a Sustainable Future
- Case Study: Innovative Agrochemical Product Development — From Concept to Market
- Whitepaper: Optimizing Process Scale-Up in Agrochemical CDMO Operations
- Blog: How Integrated CDMO Models Accelerate Agrochemical Time-to-Market