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Innovative Payloads for next generation ADCs.
Overview
Cohance Lifesciences is a global frontrunner in the development and supply of high-potency payloads and linkers for Antibody-Drug Conjugates (ADCs). With deep expertise in Camptothecin (CPT) derivatives and proprietary s-Trione scaffold, we offer customizable payloads with high cytotoxicity, efficient conjugation, and scalable synthesis.
Our capabilities span from early-stage R&D to GMP-compliant commercial manufacturing, all under rigorous global standards for quality, containment, and regulatory compliance. We specialize in handling ultra-potent compounds with occupational exposure limits (OEL) as low as ~10 µg/m³.
Why Cohance for Small Molecule Manufacturing?
Why Cohance for ADC Payloads?
- Global Innovator in synthetic CPT derivatives, powered by proprietary S-Trione technology.
- Expertise in High-Potency Payloads, ensuring safety, scalability, and therapeutic efficacy.
- Robust Backward Integration for consistent supply of key starting materials (KSMs), including (s)-Trione, tetralone derivative (CAS# 182182-31-6) etc.
- Sustainability Commitment, backed by ISO 14001, 45001, and 9001 certifications, with measurable ESG impact: 17% water savings, 6% CO₂ reduction, and over 33,000 trees planted.
Manufacturing Strengths
Manufacturing Strengths
Scalable Production: Flexible volumes from gram to multi-ton capacity across multiple sites.
GMP-Ready Infrastructure: USFDA-, EMA-, and PMDA-approved sites with validated processes and full traceability.
Technology-Enabled Execution: Flow reactors, high-pressure systems (up to 20 kg/cm²), cryogenic capabilities (-70°C), and automation.
Regulatory Compliance: 200+ DMFs filed globally; extensive experience in audits and global market readiness.
Lifecycle Manufacturing: Support for reprocessing, impurity purge, solvent recovery, and green manufacturing practices.
Core Capabilities
Scalable
Production
Flexible volumes from gram to multi-ton capacity across multiple sites.
GMP-Ready
Infrastructure
USFDA-, EMA-, and PMDA-approved sites with validated processes and full traceability.
Technology-Enabled
Execution
Flow reactors, high-pressure systems (up to 20 kg/cm²), cryogenic capabilities (-70°C), and automation.
Regulatory
Compliance
200+ DMFs filed globally; extensive experience in audits and global market readiness.
Lifecycle
Manufacturing
Support for reprocessing, impurity purge, solvent recovery, and green manufacturing practices.
CPT Derivative
Expertise
Advanced synthetic routes for Exatecan Mesylate, SN-38, Irinotecan, Topotecan, 10-Hydroxy Camptothecin, and more, with integrated supply of intermediates like (s)-Trione (CAS# 110351-94-5).
Regulatory
Strength
Active Drug Master Files (DMFs) for S-Trione (US DMF 039042), SN-38 (US DMF 039031), Irinotecan (CEP 2023-338) and with upcoming DMFs for Exatecan, Dxd, Belotecan and MMAE.
Proprietary
s-Trione Platform
Engineered payloads with superior stability and therapeutic index, enabling precision-targeted ADCs.
Auristatin
Development
Optimized processes for Monomethyl Auristatin E (MMAE), ensuring impurity control and batch consistency.
GMP Manufacturing
Excellence
Multi-kilogram production in specialized cytotoxic facilities, supporting both clinical trials and commercial supply.
Custom Payload
Synthesis
Tailored derivatives based on cytotoxicity profile and linker compatibility.
Linker
Development
Maleimide, hydrazone, and proprietary cleavable/non-cleavable linkers.
Facilities
Genome Valley R&D Center: 25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites: Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites: Plug flow reactors, Corning G1 systems, and photo flow platforms.
Payload & Linker Services
Cohance Lifesciences offers end-to-end payload and linker development tailored to the evolving needs of Antibody-Drug Conjugates (ADCs). Our services combine scientific precision with scalable manufacturing to ensure consistency, safety, and regulatory compliance.
Our Expertise
Process
Optimization
Scalability studies, impurity profiling, validation under Quality by Design (QbD) principles and analytical method development & validation.
Custom Payload
Synthesis
Tailored Camptothecin (CPT) and Auristatin derivatives designed for optimal cytotoxicity and linker compatibility.
Linker
Development
Synthesis of industry-standard and proprietary linkers, including: Maleimide, Hydrazone, SMCC, MC-VC-PAB, PNP-PAB-m-PhosphatePEG8-DBCO
Containment
Expertise
Safe handling of high-potency compounds in both R&D and GMP settings using isolators and negative pressure systems.
Genome Valley R&D Center
25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites
Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites
Plug flow reactors, Corning G1 systems, and photo flow platforms.
Facilities
We operate a robust network of cutting-edge small molecule development and manufacturing facilities across India. Our infrastructure spans lab-scale discovery to large-scale commercial manufacturing — enabling faster, flexible, and scalable solutions for your drug development needs.
Genome Valley R&D Center
25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites
Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites
Plug flow reactors, Corning G1 systems, and photo flow platforms.
Our early-stage R&D and kilo labs are designed to support route scouting, process development, and scale-up studies.
API R&D Unit-III, Nacharam
Hyderabad, India
API Unit IV, Nacharam
Hyderabad, India
API Unit V, Parwada
Vizag, India
Designed to seamlessly scale from clinical to commercial manufacturing, these facilities are compliant with global regulatory standards including the US FDA.
Genome Valley R&D Center
25,000 sq. ft. of dedicated process development and safety labs.
Commercial Manufacturing Sites
Multi-ton capacity, including facilities for HPAPIs, phosphoramidites, and other complex chemistries.
Flow Chemistry Suites
Plug flow reactors, Corning G1 systems, and photo flow platforms.
Facilities
GMP Multi-Kilo Facility
Nacharam, Hyderabad
Equipped for high-potency manufacturing, this facility features:
• Reactors: Stainless steel (1,500 L) Glass-lined (630 L) and various small reactors
• Drying Systems: Agitated Nutsche Filter Dryers (ANFDs, 350 L) and vacuum tray dryers (6 trays)
Advanced Processing
Capabilities
• Particle Size Reduction: Jet mills (100 mm) and multi-mills (10–24 kg/hr)
• Containment: Isolators for sampling, dispensing, and powder processing
Isolator Suites for
Cytotoxic Compounds
• Containment Design: Negative pressure environments (-75 to -125 pa)
• Air Handling: Dynamic pass-boxes and BIBO HEPA-filtered AHUs
• Cleanroom Classification: Maintained at ISO-8 standards
Design Philosophy for
Safety & Compliance
• Personnel Flow: Dedicated entry/exit routes with mist showers
• Access Control: Door interlocks
• Environmental Safety: Integrated detoxification systems for effluent treatment
Proprietary
s-Trione Platform
Engineered payloads with superior stability and therapeutic index, enabling precision-targeted ADCs.
Auristatin
Development
Optimized processes for Monomethyl Auristatin E (MMAE), ensuring impurity control and batch consistency.
GMP Manufacturing
Excellence
Multi-kilogram production in specialized cytotoxic facilities, supporting both clinical trials and commercial supply.
Custom Payload
Synthesis
Tailored derivatives based on cytotoxicity profile and linker compatibility.
Linker
Development
Maleimide, hydrazone, and proprietary cleavable/non-cleavable linkers.
From grams to tons-trust Cohance to deliver your small molecule at scale.
Contact Manufacturing Team
Securing your ADC payload supply chain?
Let’s partner.
Contact UsResources
- Webinar: Scaling High-Potency Payloads for Clinical and Commercial Supply
- Case Study: Multi-Kilo Production of Exatecan Under Containment
- Whitepaper: Innovations in Camptothecin-Based Payload Synthesis
- Blog: What Makes a Reliable Payload Partner in the ADC Ecosystem?
Resource Highlights
Webinars
Navigating Regulatory Audits in Small Molecule Manufacturing
Whitepapers
Smart Scale-Up Using Flow Chemistry
Case Studies
Seamless Tech Transfer of a Multi-Step Synthesis
Blog
Building Sustainable API Supply Chains
Webinars
Navigating Regulatory Audits in Small Molecule Manufacturing
Whitepapers
Smart Scale-Up Using Flow Chemistry
Case Studies
Seamless Tech Transfer of a Multi-Step Synthesis
Blog
Building Sustainable API Supply Chains
Our Global Accreditations
At Cohance Lifesciences, every facility stands as a testament to our commitment to uncompromised quality. Below is a snapshot of regulatory approvals and certifications across our global network
API Manufacturing Facilities
API Unit I
• US FDA, EU, PMDA, Russia MOH, KFDA, COFEPRIS, CDSCO, DCA, WHO GMP
API Unit II
• EU, DCA
API Unit III
• US FDA, EDQM, PMDA, KFDA, ANVISA, COFEPRIS, CDSCO, DCA
API Unit IV
• US FDA, EU, CDSCO, DCA
API Unit V
• ISO, DCA
Formulation (FDF) Facilities
FDF Unit I
• US FDA, Health Canada, MHRA, ANVISA, COFEPRIS, Russia MOH, TGA, Philippines FDA, Tanzania FDA, Greece NOM, Uganda NDA, Germany, SFDA, CDSCO, DCA
FDF Unit II
• CDSCO, DCA
Clinical Research
CR Bio
• US FDA, DCGI, MOH Turkey, BPFK Malaysia, WHO Geneva, MHRA, GCC, NPRA Malaysia
Suven Pharma Sites
Unit 1 to Unit 4, and Unit 6
• British Safety Council, International Safety
• ISO 20400:2017, ISO 22301:2019, ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, ISO 50001:2018
Unit 5
• US FDA, DCA, PPD Global Quality Compliance, EU, CDSCO
• ISO 22301:2019, ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, ISO 50001:2018
Casper
• US FDA, DCA
Our ESG Aspirations
Cohance is committed to a sustainable future with ambitious goals:
- Net-Zero Emissions by 2050: Focusing on decarbonization, renewable energy, and resource efficiency, aligned with Science-Based Targets (SBTi).
- Environmental Sustainability: Enhancing green practices through sustainable procurement and biodiversity protection.
- Social Impact: Expanding community engagement in health, sanitation, and water access, while supporting economic development through CSR initiatives.
- UN SDG Alignment: Contributing to goals like Good Health and Well-Being, Clean Water and Sanitation, and Responsible Consumption and Production.
- Ethical Governance: Strengthening transparency, ethics, and responsible sourcing through global initiatives like the Pharmaceutical Supply Chain Initiative (PSCI).
At Cohance, ESG is our promise to go above and beyond, shaping a sustainable future for health science through passion, expertise, and unwavering responsibility.
History
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Experience
Our great team of more than 1400 software experts.
Quick Support
We’ll help you test bold new ideas while sharing your.
Leadership Team
John Smith
CEO
Emma London
Co-Founder
Jessica Brown
Managing Director
Christine Eve
Designer
Sustainability
ESG
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EHS
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Quality & Compliance
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We deal With The Aspects Of Professional IT Services
About usEngitech is the partner of choice for many of the world’s leading enterprises, SMEs and technology challengers. We help businesses elevate their value through custom software development, product design,
Experience
Our great team of more than 1400 software experts.
Quick Support
We’ll help you test bold new ideas while sharing your.
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440
employees from around the world
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happy clients from largest corporations
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offices in 6 counties worldwide
We deal With The Aspects Of Professional IT Services
About usEngitech is the partner of choice for many of the world’s leading enterprises, SMEs and technology challengers. We help businesses elevate their value through custom software development, product design,
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