Sapala Organics, IDA Mallapur
Telangana, India
Sapala Organics, IDA Mallapur
Telangana, IndiaSapala Organics is a pioneering force in nucleic acid innovation in India. With over a century of combined expertise across 18 laboratories, the company specializes in modified nucleosides, advanced building blocks, and custom phosphoramidites that enable breakthrough therapies. Following its acquisition by Cohance Lifesciences, Sapala now integrates three decades of Cohance’s CDMO excellence, reinforcing its role as a trusted global partner in nucleic acid chemistry and oligonucleotide-based therapeutics.
Key offerings: Nucleic acid chemistry and oligonucleotide-based therapeutics
Sapala Organics, IDA Mallapur
Telangana, India
Capabilities
- Sugar-Modified Chemistry
- Base-Modified Chemistry
- Backbone-Modified Chemistry
- Nucleotide Chemistry
- Linkers & Spacers
- Solid-Support Synthesis
- Lipids and drug delivery compounds
- Custom oligonucleotide synthesis using modified phosphoramidites
Production Capacity
- Gram-to-kilogram scale synthesis of nucleosides, nucleotides, and phosphoramidites
- Custom synthesis of modified phosphoramidites: mg to multi-kg scale
- Lipids and drug delivery compounds: mg to multi-kg scale
Research & Development
- Contract Research Services under CRO model with Full-Time Equivalent (FTE) scientists
- Embedded scientific teams for collaborative, long-term partnerships
- Tailored R&D programs ensuring deep alignment with client objectives
Process Development
- Scale-up of modified phosphoramidites and nucleoside triphosphates
- Process development of oligonucleotides using modified phosphoramidites
- Process optimisation of various of drug delivery compounds such as GalNAc
- Development of custom linkers, spacers and fluorescent dyes
Manufacturing
- CDMO services in nucleic acid chemistry for global clients
- Integrated expertise in oligonucleotide-based therapeutics
- Part of Cohance Lifesciences network, ensuring world-class standards
Equipment & Utilities
- Spectroscopy & NMR: FTIR (2), NMR (400 MHz, 500 MHz)
- Chromatography: HPLC (9 systems: UV, RI, ELSD, CAD), GC, GC-HS, UPLC
- Spectrometry: UPLC(2), LC-MS (2), GC-MS, LC-MS/MS, ICP-MS
- Spectrophotometry: UV, Polarimeter, Optical rotation, Specific optical rotation
- Thermal Studies: DSC, TGA, Melting/Boiling point analysis
- Wet Analysis: Autotitrator, Gravimetric, Argentometric, Heavy metal analysis, ROI, KF Coulometer, Conductivity, KF Titrator
- Oligonucleotide Equipment: Akta Oligosynth; Akta Oligopilot-10 and NTS-24 column synthesiser
Accreditations & Certifications
- ISO 9001:2015; ISO 27001: 2013 and ISO 27701:2019
Capabilities
Multi-scale cGMP intermediate & API manufacturing
Production Capacity
Total Reactor Volume: 406 KL
Annual Output Capacity: XXX MT
Block-wise Capacity:
| Block | Capacity | Key Features |
|---|---|---|
| Block A | 60 KL | Intermediate Manufacturing |
| Block B | 166 KL | API Manufacturing |
| Block C | 110 KL | High-Potency Handling |
| Block D | 10.5 KL | Pilot Scale Production |
Equipment & Utilities
Reactor Types
- Glass-lined
- Stainless Steel
Reactor Range
From [XX L] to [YY KL]
Key Equipment
- Centrifuges
- Dryers (ANFDs, Tray Dryers, RCVDs)
- Distillation Units
- Micronizers
Utilities Infrastructure
- HVAC Systems
- Boilers with backup power
- Chillers and Cooling Towers
- Purified Water and WFI Systems
- Nitrogen Generation Plant
- Reactor Types: Glass-lined, Stainless Steel
- Reactor Range: From [XX L] to [YY KL]
- Key Equipment:
- Centrifuges
- Dryers (ANFDs, Tray Dryers, RCVDs)
- Distillation Units
- Micronizers
- Utilities Infrastructure:
- HVAC Systems
- Boilers with backup power
- Chillers and Cooling Towers
- Purified Water and WFI Systems
- Nitrogen Generation Plant
Accreditation
History
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