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Antibody Drug Conjugates (ADCs) - Payload Supply
Overview
NJ Bio, a Cohance Lifesciences company, is a global leader in the development and supply of high-potency payloads and linkers for Antibody-Drug Conjugates (ADCs). We specialize in Camptothecin (CPT) derivatives and proprietary S-Trione scaffolds—designed for high cytotoxicity, optimal conjugation, and scalable synthesis.
Our payload supply solutions span R&D through GMP commercial production—meeting the highest standards of quality, containment, and regulatory compliance.
Core Capabilities
Core Capabilities
CPT Derivatives Mastery: Expertise in Exatecan Mesylate, SN-38, Irinotecan, and Topotecan derivatives.
Proprietary S-Trione Platform: Novel payloads with enhanced stability and therapeutic index.
GMP Manufacturing: Fully synthetic routes enabling multi-kg batch production under strict containment.
Regulatory Ready: DMF filings for key payloads including Exatecan and MMAE (expected Oct–Nov 2025).
Payload & Linker Services
Custom Payload Synthesis: Tailored derivatives based on cytotoxicity profile and linker compatibility.
Linker Development: Maleimide, hydrazone, and proprietary cleavable/non-cleavable linkers.
Process Optimization: Scalability assessments and impurity fate studies.
Containment Excellence: Handling of compounds with OEL < 20 ng/m³ in both R&D and GMP environments.
Infrastructure Snapshot
Infrastructure Snapshot
GMP Multi-Kilo Facility: Equipped with glass-lined, SS, and Hastelloy reactors up to 1,500 L.
Advanced Drying & Milling: Jet mills, vacuum dryers, ANFDs for precise powder handling.
Isolator Suites: For kilo-scale payload synthesis with dedicated containment zones.
Why Cohance for Payload Supply?
Specialized in high-potency payloads for ADC applications
Proprietary platforms and scalable synthetic methodologies
Strong backward integration and supply reliability
Regulatory track record and global compliance
Secure your payload supply chain with a partner that delivers innovation, consistency, and confidence.
Request Payload Capabilities Brochure
Resources Highlights
Resources Highlights
Webinar: Scaling High-Potency Payloads for Clinical and Commercial Supply
Whitepaper: Innovations in Camptothecin-Based Payload Synthesis
Case Study: Multi-Kilo Production of Exatecan Under Containment
Blog: What Makes a Reliable Payload Partner in the ADC Ecosystem?
Our Global Accreditations
At Cohance Lifesciences, every facility stands as a testament to our commitment to uncompromised quality. Below is a snapshot of regulatory approvals and certifications across our global network
API Manufacturing Facilities
API Unit I
• US FDA, EU, PMDA, Russia MOH, KFDA, COFEPRIS, CDSCO, DCA, WHO GMP
API Unit II
• EU, DCA
API Unit III
• US FDA, EDQM, PMDA, KFDA, ANVISA, COFEPRIS, CDSCO, DCA
API Unit IV
• US FDA, EU, CDSCO, DCA
API Unit V
• ISO, DCA
Formulation (FDF) Facilities
FDF Unit I
• US FDA, Health Canada, MHRA, ANVISA, COFEPRIS, Russia MOH, TGA, Philippines FDA, Tanzania FDA, Greece NOM, Uganda NDA, Germany, SFDA, CDSCO, DCA
FDF Unit II
• CDSCO, DCA
Clinical Research
CR Bio
• US FDA, DCGI, MOH Turkey, BPFK Malaysia, WHO Geneva, MHRA, GCC, NPRA Malaysia
Suven Pharma Sites
Unit 1 to Unit 4, and Unit 6
• British Safety Council, International Safety
• ISO 20400:2017, ISO 22301:2019, ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, ISO 50001:2018
Unit 5
• US FDA, DCA, PPD Global Quality Compliance, EU, CDSCO
• ISO 22301:2019, ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, ISO 50001:2018
Casper
• US FDA, DCA
Our ESG Aspirations
Cohance is committed to a sustainable future with ambitious goals:
- Net-Zero Emissions by 2050: Focusing on decarbonization, renewable energy, and resource efficiency, aligned with Science-Based Targets (SBTi).
- Environmental Sustainability: Enhancing green practices through sustainable procurement and biodiversity protection.
- Social Impact: Expanding community engagement in health, sanitation, and water access, while supporting economic development through CSR initiatives.
- UN SDG Alignment: Contributing to goals like Good Health and Well-Being, Clean Water and Sanitation, and Responsible Consumption and Production.
- Ethical Governance: Strengthening transparency, ethics, and responsible sourcing through global initiatives like the Pharmaceutical Supply Chain Initiative (PSCI).
At Cohance, ESG is our promise to go above and beyond, shaping a sustainable future for health science through passion, expertise, and unwavering responsibility.
History
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Experience
Our great team of more than 1400 software experts.
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Leadership Team
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Sustainability
ESG
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EHS
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Quality & Compliance
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Experience
Our great team of more than 1400 software experts.
Quick Support
We’ll help you test bold new ideas while sharing your.
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We deal With The Aspects Of Professional IT Services
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