High-Purity Building Blocks…Crafted for Performance. Ready for Scale.
Why Choose Cohance + Sapala for Oligo Building Blocks?
Why Choose Cohance + Sapala for Oligo Building Blocks?
- Trusted supplier to global biopharma companies for early and late-phase needs
- Consistent delivery at both R&D and GMP-grade scales
- Rapid support for custom synthesis
- Backed by integrated development and manufacturing
Product Categories
Nucleoside and
Phosphoramidite Derivatives
Wide range of modified amidites and nucleosides, including locked/bridged nucleic acids, FANA, oxime compounds, morpholino compounds, and diastereotopically pure amidites. Excellent impurity control (≤0.2%–0.3%). Among the few globally supplying multi-kg tri-cyclo DNA.
Linkers
and Spacers
Custom-designed chemical linkers and spacers that enhance the conjugation of oligonucleotides with targeting or delivery molecules, improving therapeutic stability and efficacy.
PEG Derivatives
GalNAc Conjugates
Sugar derivatives, lipids, and PEG-based linkers developed for targeted oligonucleotide delivery. Multi-kg scale GalNAc synthesis for clinical-stage biopharma partners.
mRNA
Building Blocks
Supply of modified NTPs and chemically synthesized N1-Me-pseudouridine at multi-kilo scale. Includes cap reagents for mRNA vaccines and therapies.
Fluorescent
Dyes
Large-scale synthesis of 6-FAM, TET, Cy3, TAMRA, Cy5, and other dyes used in molecular diagnostics, gene sequencing, and imaging platforms.
Nucleoside and
Phosphoramidite Derivatives
Wide range of modified amidites and nucleosides, including locked/bridged nucleic acids, FANA, oxime compounds, morpholino compounds, and diastereotopically pure amidites. Excellent impurity control (≤0.2%–0.3%). Among the few globally supplying multi-kg tri-cyclo DNA.
Linkers
and Spacers
Custom-designed chemical linkers and spacers that enhance the conjugation of oligonucleotides with targeting or delivery molecules, improving therapeutic stability and efficacy.
PEG Derivatives
GalNAc Conjugates
Sugar derivatives, lipids, and PEG-based linkers developed for targeted oligonucleotide delivery. Multi-kg scale GalNAc synthesis for clinical-stage biopharma partners.
mRNA
Building Blocks
Supply of modified NTPs and chemically synthesized N1-Me-pseudouridine at multi-kilo scale. Includes cap reagents for mRNA vaccines and therapies.
Fluorescent
Dyes
Large-scale synthesis of 6-FAM, TET, Cy3, TAMRA, Cy5, and other dyes used in molecular diagnostics, gene sequencing, and imaging platforms.
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