Payloads

S.No. DMF / CAS No. Product Name Status Structure
1 USDMF # 039031 SN-38 PV & DMF filing completed SN-38
2 USDMF # 043412 Exatecan mesylate PV & DMF filing completed Exatecan mesylate
3 USDMF # 043966 Camptothecin PV & DMF filing completed Camptothecin
4 To be filled MMAE GMP material supply can be done, MMAE
Plant validation in progress, will be completed by Dec 2026, DMF by Apr 2027
Topotecan Hydrochloride Lab validation in progress, PV by Mar 2027 Topotecan Hydrochloride
10-Hydroxycamptothecin Lab validation completed, Plant validation to be initiated 10-Hydroxycamptothecin
5 Cas # 1599440-33-1 Dxd Process development completed for non-GMP material supply Dxd
6 Cas # 2353529-47-0 MMAU Triflate (β-D-glucuronylmonomethylauristatin E) MMAU Triflate
7 NA Belotecan Process development in progress Belotecan

Linkers

S.No. List of Linker CAS No. Status Structure
1 Val-Cit-PAB-OH 159857-79-1 Process development completed for non-GMP material supply Val-Cit-PAB-OH
2 MC-Val-Cit-PAB-OH 159857-80-4 MC-Val-Cit-PAB-OH
3 SMCC 64987-85-5 SMCC
4 GGFG Linker 1599440-25-1 Under development for non-GMP material supply, will be completed by Jan 2027 GGFG Linker

Payload-Linkers

S.No. List Payload-Linker CAS No. Status Structure
1 Vc-MMAE 646502-53-6 Under development for non-GMP material supply Vc-MMAE
2 Deruxtecan (MC-GGFG-Dxd) 1599440-13-7 Deruxtecan (MC-GGFG-Dxd)